Most $100K+ jobs are obtained through personal referrals, so effective networking is the most important single aspect of any job search. Always be prepared to describe yourself in a single-sentence. Don't just reiterate your job history and experience. Instead, position yourself as having a specific and compelling skill set. Perhaps you're a 'sales turnaround expert' who's 'tough-minded' and 'thrives under pressure.' That's the kind of meaty characterization employers relish.
Bone up on your company's past, present, and future. If you can reference and react intelligently to what journalists, investment analysts, and others have said and written about your potential employer, you present yourself as a leader who thinks strategically, not a worker bee who waits around to be handed a new task.
Do more than Google your prospective employer. Ask around; read analyst reports when appropriate. Know what the most recent scuttlebutt is.