50 Things You Never Knew About the Making of 'Grey's Anatomy'

"It's a beautiful day to save lives."

It's hard to believe that after 13 seasons, there is still so much you don't know about hit Shonda Rhimes series Grey's Anatomy. Here, we've uncovered the most fascinating things that have slipped through the cracks over the years—the stories behind the props, the off-screen drama, and the well-kept secrets you never knew about your favorite characters. Put on your scrubs—this could get messy.

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Shonda Rhimes' first inspiration for the show came from the Discovery Channel

Grey's creator Shonda Rhimes' inspiration came from her love of the medical shows she watched on the Discovery Channel. "My sisters and I would call each other up and talk about operations we'd seen," she said in an interview with Oprah. "There's something fascinating about the medical world—you see things you'd never imagine, like the fact that doctors talk about their boyfriends or their day while they're cutting somebody open. So when ABC asked me to write another pilot, the OR seemed like the natural setting."

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And the second stroke of genius came from a doctor shaving her legs

In the same interview with Oprah, Rhimes said, "My show is more personal [than E.R.]. The idea for the series began when a doctor told me it was incredibly hard to shave her legs in the hospital shower. At first that seemed like a silly detail. But then I thought about the fact that it was the only time and place this woman might have to shave her legs."

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The show's original setting was not Seattle

Rhimes originally wanted to set Grey's Anatomy in her hometown of Chicago, but worried that doing so would make the show too similar to E.R., which was already set in there. 

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And the show's original name was not 'Grey's Anatomy'

It was originally called Complications.  

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Meredith Grey's home is a real house

You may have assumed it's a set at all, but it's a real house in Seattle.

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Isaiah Washington originally auditioned for the role of Derek Shepherd

He says of that audition, "It didn't work out, and it went exactly the way it was supposed to go. Four days later, I get a call after I was passed over from Shonda saying, 'I really wanted you in this piece so would you be interested in playing a recurring character?'" 

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Dr. Karev wasn't in the original script

Justin Chambers was brought on after the pilot episode. "The role of Dr. Karev...they shot the pilot before I came on," he said. "The character wasn't even created yet, I don't think. They sent the pilot to New York where I live and I saw it and loved it and I went out to L.A. to try to win the part and auditioned and got the role. So that's how Alex came about." 

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Sandra Oh was supposed to audition for the role of Miranda Bailey

"Thank god I did not get that part," she said.

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But she told the directors and producers that she would rather audition for Christina

"At that time I was practicing asking for what I wanted in my life, which I still practice today. And I saw the part of Christina Yang and I wanted to do that part," she said. "So even though Shonda wanted me to come in for the part of Bailey, I said, 'No I want to come in for Christina.'"

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Ellen Pompeo didn't audition for the part of Meredith Grey

Shonda Rhimes and ABC network simply gave Pompeo the part. "I didn't audition for Meredith Grey; I was offered the part by Shonda and the network. Shonda Rhimes wasn't really 'Shonda Rhimes' at the time. It wasn't a big deal—it was just another pilot," she said. "My agent said, 'Just do the pilot and make some money—these things never go.' And then 12 years later…yup!

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Rhimes was very intentional about including interns

"I chose interns over established surgeons because I thought there's something really horrible about not knowing what you're doing for a living," she said.

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Rhimes didn't have a specific image in mind for each of the characters

"I wasn't really trying to pull together any specific combination of characters together when I was picking the cast," she said. "Whoever was best, that's who we were going to cast." 

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...Except for Miranda Bailey

According to Chandra Wilson, Dr. Bailey was originally imagined as "a short, white, blonde female." Shonda said that Bailey was, "The only character who had a description."

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So Chandra Wilson didn't think she could audition for the part

"I wasn't seen for it for a while and then finally casting in New York saw me because she'd known me for years and said, 'Why not,'" Wilson said

"Honestly the reason we were so reticent about talking to her after she auditioned in L.A. was because she was perfect," said Rhimes. "We thought if we spoke to her we would all convey, 'Oh my god please we want you,' as opposed to letting things happen the way they're supposed to." 

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Patrick Dempsey didn't know his character was married until the middle of Season 1

"You really don't know what's going to happen from day to day most of the time," said Dempsey. "Stuff is always being rewritten and changed and storylines are being revealed to you. You really have to think on your feet. I didn't know I was married until halfway through."

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And Pompeo didn't know until the end of Season 1

"They didn't tell me that was coming," said Pompeo. "I was very surprised." 

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Real surgeons are brought in for the surgery scenes

Executive Producer Jim Parriott said, "We have a really terrific medical producer, Linda Klein, who stages these operations and brings in real surgeons so the handwork you see a lot of the time is a real surgeon tying a knot." 

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The organs used are real

Well, they come from cows (mostly). 

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Addison Shepherd was only supposed to be on for a couple of episodes

"Initially it was just probably going to be a few episodes...come in like a badass from New York and that'll be that," Kate Walsh said

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Patrick Dempsey thought Shonda Rhimes hated him

"So I got into the room and [pilot director] Peter [Horton]'s very warm, very loving towards me...we reconnect," he said. "And then Shonda Rhimes looks at me. No expression, just looks at me. The entire meeting, just looking at me. No expression, no warmth, nothing. Everybody else is talking, it's very quiet, and then I leave. I call my agent and I'm like, 'It's not going to work at all. Shonda Rhimes hates me.' I was completely terrified; she's scary." 

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Katherine Heigl shares a lot in common with her character

"The writers incorporate a lot of our own personalities into the characters. I cook, I bake, I knit. Izzie's the super moral version of me," Heigl said

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Ellen Pompeo said the best thing about kissing Patrick Dempsey is the lack of guilt

"His wife Jill is very, very nice and very understanding, as is my boyfriend Chris," she said. "So we're completely guilt-free." 

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At the start of the series, Justin Chambers had five kids and a wife of ten years

In an interview with Oprah, Katherine Heigl said, "I think one of the best-kept secrets of our show is that Justin has five kids and has been married for ten years." 

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Katherine Heigl read one full book every day on set

"This pretty blonde will read a book a day on set. I'm not kidding you, a book a day," said Justin Chambers. 

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T.R. Knight was the funny one on set

"T.R. keeps us all laughing, just continually," said Heigl. "He's got the best sense of humor on set." 

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The cast follows real-life doctors

"One of my best, best-kept secrets is that I continue to train with real doctors," said Isaiah Washington. "I go to open heart surgeries whenever I can or brain surgeries whenever I can. That just helps me keep my edge." 

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Kate Walsh thought Derek and Addison should have been together

"The best thing for everybody involved, I feel, is that Derek and Addison really should be together," she said

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James Pickens lassos in his free time on set

"It kind of gets me relaxed and ready to roll," he said

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A lot of the medical stories are adapted from real-life events

"[They're] from articles that we find in the paper or sometimes we sit in a room and say, 'Is this possible, could this happen', run to the door, ask our medical researcher, 'can this happen,' and she comes back and says, 'yeah you can impale two people on a pole and they can still be talking,' or 'yeah an entire hospital staff can get syphilis,'" said Shonda

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Isaiah Washington was fired from the show for using a homophobic slur

Washington used a homophobic slur in regard to co-star T.K. Knight and was subsequently fired. As a result, his return to the show in 2014 sparked a major controversy

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