The ‘Grey’s Anatomy’ Cast in Their First Season vs. Their Last

Be honest: Did you even remember all of these characters were on the show?

Grey's Anatomy Then and Now
(Image credit: Getty Images)

The staff at Grey Sloan Memorial Hospital (formerly Seattle Grace Hospital...and Seattle Grace Mercy West Hospital) is ever-changing. As Grey's Anatomy barrels along through its second decade on the air, it's only natural that the actors who make up its cast have changed. Yes, some characters have left Seattle and been replaced by new ones, but the longer the actors stay on the show, the more they change themselves (again, a totally natural thing—that's just how time works). Here's a look back at the Grey's Anatomy cast in their first seasons on the show and in their last. Keep scrolling to the very end to see how the long haul cast members—stars like Ellen Pompeo and Chandra Wilson, who have been with the show since season one—have changed in their 16 years and counting on the show.