The 20 Best Acne Spot Treatments to Shrink Pimples, Stat

Smaller zits in 24 hours? Count us in.

best acne spot treatments collage
(Image credit: Brittany Holloway-Brown/Future)

When an uninvited guest (read: pimple) decides to pop up, it’s easy to go straight into panic mode. But instead of picking, popping, and causing even more inflammation, your first instinct should be to reach for one of the best acne spot treatments. Because the truth is: A drying lotion, pimple patch, or other acne spot treatment is going to be the quickest, most effective, and least irritating method to shrink your unwanted zit. “Acne spot treatments often contain ingredients that expedite wound healing and dry up any oozing, which improves skin quickly and certainly speeds up the pimple process,” says Dr. Rachel Nazarian, board-certified dermatologist at Schweiger Dermatology Group in New York City. 

Giving a targeted dose of salicylic acid or benzoyl peroxide to your little friend can make it look a whole lot smaller in just 24 to 48 hours. As for *exactly* which product you’ll want to use to get the pimple-shrinking job done? A lot of it boils down to personal preference and skin type. There are superpowered drying gels great for pussy pimples (lookin’ at you Mario Badescu), invisible patches for a daytime treatment, and gentle pastes formulated specifically for those with sensitive skin. Here, we’ve rounded up the best acne spot treatments of all time—and answered every question you could possibly have about using ‘em. 

How Does a Spot Treatment Work?

Let’s lay some ground rules: An acne spot treatment isn’t the best course of action for someone with acneic skin. If that’s the case, you’ll want to work with a dermatologist and go on a skincare routine for acne-prone skin. That said, a spot treatment is one of most effective ways to treat a particularly angry or unexpected pimple. 

“Acne spot treatments work by delivering direct levels of anti-inflammatory ingredients to quickly decrease the redness and swelling associated with pimples,” explains Dr. Nazarian. Because a spot treatment is typically occlusive, aka it forms a protective barrier on the outside of your pimple, it’s able to “enhance the delivery of topical ingredients and stimulate healing.” 

Will a Spot Treatment Shrink All Kinds of Pimples?

A spot treatment is going to work best on inflamed papules and pustules that need to be calmed down or dried up. When it comes to blackheads, Dr. Nazarian explains that spot treatments will be effective—but it’s going to take a lot longer to see results. “An acne leave-on cream works just as good if not better for blackheads,” she says. As for cystic acne, aka those under-the-skin pimples? “Spot treatments don’t really help the ones you feel, but can’t see because they’re too deep for the medicine to really get there and break up the pimple,” adds Dr. Morgan Rabach, board-certified dermatologist and co-founder of L.M. Medical in New York City. If your cyst pimple is particularly painful, visit your board-certified dermatologist for a cortisone injection. 

When Do I Use a Spot Treatment?

Adding a spot treatment into your skincare is easy as can be—most can be used in the morning or night and should be applied directly after your moisturizer. “You can combine spot treatments with the rest of your regiment, especially with non-irritating products like hyaluronic acid,” says Dr. Nazarian. While combining spot treatments with hydrating and calming products is a plus, Dr. Rabach does suggest thinking twice before combining a spot treatment with other acids or retinols, as it can be overly drying—especially for those with dry or sensitive skin. 

While sunscreen should always be the final step in your morning skincare routine, wearing SPF is even more important if you’re using a spot treatment. “Ingredients in spot treatments can increase sun sensitivity and hyperpigmentation,” explains Dr. Rabach. She recommends looking for a physical formula with titanium dioxide or zinc as the active ingredient. (We also hand-picked our favorite sunscreens for acne-prone skin.)

What Should I Look for in a Spot Treatment?

Every spot treatment on our list is a winner—but selecting the right one for your specific skin type and concerns boils down to the ingredient list. Dr. Nazarian explains that benzoyl peroxide is “wonderful for killing bacteria that can lead to pimples” and is ideal for deeper, red zits. Salicylic acid on the other hand is preferable for treating blackheads and whiteheads. Dr. Rabach adds that ingredients like sulfur and zinc are particularly calming and anti-inflammatory, while a spot treatment with lactic or kojic acid (both have exfoliating properties) will be beneficial to anyone dealing with hyperpigmentation. If you have sensitive skin, make sure to seek out a product with soothing ingredients like aloe vera or niacinamide. 

The Best Acne Spot Treatments

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