![](https://hips.hearstapps.com/hmg-prod.s3.amazonaws.com/images/gettyimages-1327669397.jpg?crop=1.00xw:0.755xh;0,0.115xh&resize=320:* ""Stillwater" Red Carpet - The 74th Annual Cannes Film Festival")
OK, Conan. Let's just think of this as a learning experience: Never subtweet a septuagenarian and think you can get away with it, because she will see it, and she will trounce you at your own game.
To while away the time on a rainy Thursday afternoon, the comedian posted the following comment, unknowingly inciting a conflict the likes of which have never been seen before:
Ooooooh. A critical hit! (Aside: She knows about the period! We always forget the period! How is she THIS GOOD?)
Conan still seems pretty psyched at this point—it's not every day you have a Twitter beef with the first female Secretary of State, after all—but Madeleine's not letting him off this easily.
Can we just declare a KO right now? Because he's not getting up from that one.
BOOM. And with that, Conan slinks away.
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Image via Getty
![](https://hips.hearstapps.com/hmg-prod.s3.amazonaws.com/images/gettyimages-76215117-1634295507.jpg?crop=0.840xw:0.639xh;0.142xw,0.154xh&resize=480:* ""Crossroads" Hollywood Premiere")