The 'Grey's Anatomy' Season 15 Cast Looks a Little Different

New character additions mean there'll be even more drama at Grey Sloan Memorial.

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What's Grey's Anatomy without the Meredith Grey? Exactly. While there have been massive changes throughout the show's 15 (!) seasons — we're looking at you, McDreamy! — the upcoming season will be a perfect blend of old and new characters, including a few not-so-forgotten faces from the early days. Who says change is a bad thing? Not us. Or Shonda Rhimes.

Here, a confirmed list of the major characters who will make us smile/laugh/sob during season 15, which debuts on September 27:

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1 Ellen Pompeo as Dr. Meredith Grey
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In 2018, Pompeo became the highest paid actress on a primetime drama— and rightfully so — by signing a contract with Grey's through season 16. (FYI, this covers her through 2020.) For Dr. Grey, this season is all about her kids (Zola, Derek, and Ellis Shepherd) and her groundbreaking surgery work. "Meredith [is going to] have a new trajectory that is more focused on who she is as a single mother and surgeon — including her emotional investigation into a medical condition that is very close to her own family background and history," ABC entertainment president Channing Dungey told TVLine.

2 James Pickens Jr. as Dr. Richard Webber
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There's been a lot of drama for Dr. Webber, the former Chief of Surgery, in recent years. His wife died. His long-lost daughter showed up (Dr. Maggie Pierce). Then he fell in love with Dr. Catherine Fox ... and fell out of love ... and fell back in love. Season 14 ended on good terms for Dr. Webber but now some fans are speculating that this might be his final season on Grey's. As of right now, there isn't any truth to the rumor — just speculation.

3 Jesse Williams as Dr. Jackson Avery
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Dr. Avery can finally move on: His ex-wife Dr. April Kepner is now officially out of the picture. In the last season's finale episode, Dr. Kepner married her longtime love Matthew Taylor, a paramedic who worked at the hospital. So, does that mean Dr. Avery will find love of his own? It's possible. For most of season 14, he was linked to Dr. Maggie Pierce — and the only thing preventing them from getting serious was Dr. Kepner. Since she's moved on, he can too.

4 Kelly McCreary as Dr. Maggie Pierce
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Fans of Dr. Pierce and Dr. Avery's relationship were thrilled to see the couple attend Dr. Karev and Dr. Wilson's wedding together. Yes, as an official couple. It's been a long time coming, eh? But her love story isn't her sole focus in the upcoming season: "This time, she finds herself in the middle of the Teddy, Amelia, and Owen drama," McCreary told E. "You know how Maggie feels about secrets and now she's going to be in the middle of all of that."

5 Chandra Wilson as Dr. Miranda Bailey
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In the finale, Dr. Bailey offered her role of Chief of Surgery to Dr. Teddy Altman so that she could focus more on why she fell in love with surgery in the first place. The motivation: In the previous season, Dr. Bailey had a heart attack that reminded her of the brevity of life — but once she healed, she went back to her day-to-day life. Now it looks like she's making a change — for good.

6 Justin Chambers as Dr. Alex Karev
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ICYMI: Dr. Karev is now a married man! In the finale episode, he married Dr. Jo Wilson — and to make it even sweeter, Dr. Grey officiated the ceremony. First comes love, then comes marriage ... and then comes difficult decisions. After getting married, Karev found out that his wife Dr. Jo was accepted into an esteemed fellowship program on the other side of the country. Does that mean his days at Grey Sloan Memorial Hospital are almost over? No word yet. As of right now, we know that the new season will kick off with the newlyweds relaxing on their honeymoon.

7 Camilla Luddington as Dr. Jo Karev
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Speaking of Dr. Jo Karev, her acceptance into the Boston fellowship program was THE. BIGGEST. CLIFFHANGER. EVER. But based on recent reports it seems like the Karevs are sticking around Seattle. "Jo becomes inspired and she feels like she has a new medical innovation. She wants to pursue it with Meredith in Seattle," Luddington told E. Beyond this big decision, it looks like we may get to know Dr. Jo on a deeper level in season 15 — or at least that's what Luddington is aiming for. "I do hope that at some point Jo does find out who her family is," she told TVLine. "I feel like that's the final mystery behind her that she doesn’t know any information on."

8 Kim Raver as Dr. Teddy Altman
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Let's talk about Dr. Altman's shocking pregnancy reveal. We last saw Dr. Altman in the season 8 finale when she left her former love, Dr. Hunt on not-so-good terms to accept a job in the military. But she's back with a new job at Grey Sloan: Dr. Bailey named her the Interim Chief of Surgery. But get this: She's pregnant and people are suspecting that Dr. Hunt is the father. OH. SNAP.

9 Kevin McKidd as Dr. Owen Hunt
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With two heartbreaking divorces under his belt (first with Dr. Cristina Yang and then with Dr. Amelia Shepherd), you'd think the Chief of Trauma Surgery would take a step back from romance for at least one season — or even an episode. Nope, not this charmer. Fans are speculating that he's the father of Dr. Altman's baby and as of right now, that seems like the most plausible option. Regardless, McKidd revealed that there's another infamous Grey's Anatomy-style love triangle on the horizon for Dr. Hunt. Surprise, surprise.

10 Caterina Scorsone as Dr. Amelia Shepherd
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Enter the other member of love triangle. A few seasons back when Dr. Shepherd, the Head of Neurosurgery, discovered that she had a brain tumor, her relationship with Dr. Hunt took a turn. "Him and Amelia fell in love, got married, and found out this tumor that she had," McKidd, who plays Dr. Hunt, told E. "Now, they're looking at it like maybe we are meant to be, maybe that tumor was just a stumbling block. There's some genuine stuff there."

11 Giacomo Giannotti as Dr. Andrew DeLuca
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We can't stop thinking (okay, laughing) about Dr. DeLuca's drunken kiss with Dr. Grey at the end of season 14. The surgical resident has had his fair share of ups and downs — and the end of last season was definitely his biggest down yet. You know what that means: Things can only go up from here.

12 Jeff Perry as Thatcher Grey
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Before Jeff Perry became Cyrus Beene on Scandal, he played Meredith's father on Grey's Anatomy. And if you've been watching the show since the beginning, you know that he wasn't the most loved character on the show, especially by his own daughter. He's back for season 15 but the reason for his return is up in the air.

13 Chris Carmack as "Ortho God"
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If we can't have McDreamy or McSteamy, we might as well have Ortho God, right? Meet Grey Sloan Memorial's newest doctor, played by Nashville's Chris Carmack. Details are slim but it seems like he'll shake some things up in Seattle.

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