The 18 Best Face Serums Packed With Potent Actives for Every Skin Type and Concern

Discover the quickest way to a smoother, clearer complexion.

a collage on yellow background of a woman holding a glass dropper with colorful bottles of serums around her
(Image credit: Future)

Ask any dermatologist or beauty editor what product has the power to truly transform their skin, and they’ll likely point you toward a serum. Lightweight, ultra-concentrated, and designed to target specific concerns, serums are the heavy lifters of any skincare routine. I see them as a unique, personalized step—powerful enough to tackle everything from dullness to breakouts, depending on what my skin needs most.

So, what makes a serum different from a daily moisturizer? Licensed esthetician Amy Wyman explains that, “Serums are formulated with higher concentrations of active ingredients to target specific skin concerns like uneven tone, lines, acne, or dullness. Moisturizers, on the other hand, focus on hydration and creating a protective barrier.” That’s why serums are uniquely positioned to deliver visible results—whether your goal is brightness, firmness, or skin repair.

Board-certified dermatologist Andrea Austin, MD, agrees, noting that "a well-formulated serum can do what moisturizers and cleansers can’t." The lightweight, targeted formula helps key ingredients work where they're needed most, she explains. Wyman highlights that serums are “the most effective in targeting very specific skin issues,” but warns against product overload. “There’s no need to use multiple products with the same ingredient—it can be too much for the skin and not cost-effective. Look for multi-faceted formulas that address multiple concerns." If you have sensitive or reactive skin, this is especially true, and Dr. Austin says to evaluate the ingredients carefully. "I steer clear of drying alcohols, synthetic fragrance, and essential oils. Stick to high-science, high-integrity formulations," she says.

And yet, with so many bottles promising smoothness, brightness, plumpness, and more, it’s easy to feel overwhelmed. Not sure where to start? I've done the work to decode it all. Whether you’re looking for a no-fuss hydrating serum packed with hyaluronic acid or something more targeted—like a dark spot corrector, a fine-line fighter, or a calming, barrier-repairing option—you’ll find a match here. Ahead, the 18 best face serums for every skin type, concern, and budget.

The Best Face Serums

dieux

Before, during, and after application of the Dieux Deliverance Antioxidant & Niacinamide Serum

(Image credit: Future)

Skinceuticals CE Ferulic

Before and after application of the SkinCeuticals C E Ferulic.

(Image credit: Future)

XO8 Cosmeceuticals

Before and after application of the XO8 Cosmeceuticals Vital Restorative Elixir.

(Image credit: Future)

night moisturizer (1)

Before, during, and after application of the La Mer The Night Recovery Concentrate Treatment.

(Image credit: Future)

Tata Harper Superkind Bio-Barrier Serum

Before and after application of the Tata Harper Superkind Bio-Barrier Serum.

(Image credit: Future)

Aēsop Parsley Seed Anti-Oxidant Intense Serum

Before, during, and after application of the Aēsop Parsley Seed Anti-Oxidant Intense Serum.

(Image credit: Future)

Joanna Vargas Rejuvenating Serum

Before and after application of the Joanna Vargas Rejuvenating Serum.

(Image credit: Future)

What Are The Benefits of Using a Face Serum?

Face serums are lightweight, ultra-concentrated treatments that deliver active ingredients deep into the skin. Their smaller molecular structure allows them to penetrate super effectively, targeting specific concerns such as hydration, fine lines, dark spots, or loss of firmness.

Because they’re designed to address particular issues, serums often feature powerhouse ingredients—such as hyaluronic acid for hydration, vitamin C for brightening, retinoids for skin cell turnover, or peptides for strengthening the skin barrier. They’re essentially the problem-solvers of your routine, working behind the scenes to boost results you can actually see.

Unlike cleansers or moisturizers, which focus on surface-level benefits, serums act as your skin’s treatment step—helping improve tone, texture, and resilience over time. Whether your goal is glow, clarity, or repair, the right serum can be the make-or-break product in your regimen.

What to Look For In a Face Serum

  • Ingredients:

A great serum is all about high-performance, targeted ingredients that address specific skin concerns. Wyman says that serums are “the most effective in targeting specific skincare issues,” and recommends looking for multi-factorial formulas that do more than one job.

For hydration, hyaluronic acid, glycerin, panthenol, and squalane plump the skin and support barrier health. To brighten and even skin tone, vitamin C, niacinamide, and licorice root extract are excellent choices. Anti-aging benefits often stem from peptides, retinol, and growth factors, which help boost collagen, smooth fine lines, and enhance skin elasticity.

  • Skin Type

Choosing the right serum starts with understanding your skin type. Dry or dehydrated skin benefits from hydrating ingredients like hyaluronic acid, glycerin, and squalane to restore plumpness and moisture. Oily or combination skin responds well to lightweight, fast-absorbing formulas that regulate oil, unclog pores, and prevent breakouts without feeling heavy. Aging or mature skin often responds well to peptides, retinol, and antioxidant-rich formulations, which help boost firmness, smooth fine lines, and protect against environmental stressors. Sensitive or reactive skin thrives on soothing, barrier-repairing ingredients such as ceramides, aloe, and chamomile, which help calm irritation and strengthen the skin.

For sensitive or reactive skin, Dr. Austin also recommends gentler exosome-based serums, which work by acting as tiny messengers your cells release that carry proteins and signals to help other cells repair, regenerate, and communicate. As a result, your skin acts younger and heals faster, which shows up as more glow, firmness, and resilience. Exosome serums are also ideal for anyone new to actives or recovering from skin procedures like microneedling or lasers.

How We Tested

Editors and contributors underwent a rigorous testing period, during which they reviewed dozens of serums. After consulting with makeup experts to determine the top picks, they tested each serum for its actives, performance, texture, feel, and results to compile this list of the 18 best face serums. They also evaluated customer reviews and best-selling products across our favorite retailers.

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For more than 30 years, Marie Claire has been an internationally recognized destination for news, fashion, and beauty trends, investigative packages, and more. When it comes to the products Marie Claire recommends, we take your faith in us seriously. Every product that we feature comes personally recommended by a Marie Claire writer or editor, or by an expert we’ve spoken to firsthand.

Meet The Experts

Andrea Hui Austin
Andrea Hui Austin

Dr. Andrea Hui Austin is a partner at Bay Area Cosmetic Dermatology and a double board-certified Dermatologist. She joined the practice in 2014. Dr. Hui Austin spent many years perfecting the art of cosmetic dermatology, training in dermal fillers like Restylane and Juvéderm, wrinkle relaxers like Botox, Dysport, and Xeomin, as well as laser treatments like skin tightening and resurfacing. She also focuses on the diagnosis of skin cancers and treatment with Mohs micrographic surgery and reconstructive surgery. Dr. Hui Austin is dedicated to helping her patients achieve and maintain beautiful skin through education and a personalized skincare plan

Amy Wyman
Amy Wyman

Amy is a Master Esthetician with over a decade of experience, having graduated from the National Institute of Medical Aesthetics in 2015. She specializes in advanced treatments like Diamond Glow Facials and microneedling, known for their ability to renew, regenerate, and restore the skin. Her approach combines meticulous technique with science-driven skincare, tailoring each treatment to address her clients’ unique concerns. Since joining SkinSpirit in 2021, Amy has continued to refine her expertise alongside top practitioners in the field. 

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Isabelle Adler
Contributing Writer

Isabelle Adler is a New York–based contributing writer whose work spans fashion, beauty, and lifestyle. Her writing has been featured in Elle, Esquire, Good Housekeeping, Real Simple, and other leading publications. She loves exploring the intersection of style and culture.